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Symptoms of overdose are unlikely to occur, owing to the administration route.
The highest orally administered dose of zuclopenthixol in clinical trials was 450 mg daily.
Symptoms: Somnolence, coma, extrapyramidal symptoms (movement disorders), convulsions, shock, hyperthermia/hypothermia.
ECG changes, QT prolongation, torsade de pointes, cardiac arrest and ventricular arrhythmias have been reported when zuclopenthixol has been taken in overdose concurrently with drugs known to affect the heart.
Treatment: Treatment is symptomatic and supportive. Measures to support the respiratory and cardiovascular systems should be instituted. Epinephrine (adrenaline) should not be used, as further lowering of blood pressure may result. Convulsions may be treated with diazepam and symptoms of movement disorders with biperiden.
